What dimensions do PROs cover?

PROs capture different aspects (dimensions) of patients’ perceived health, such as symptoms, side effects, functioning, and health-related quality of life (HRQOL).

HRQOL can be defined as

…the patient’s subjective perception of the impact of her/his disease and its treatment(s) on daily life, physical, psychological and social functioning and well-being.

Because it spans multiple areas, HRQOL is multidimensional.

The figure below shows the main PRO and HRQOL dimensions and how they relate to each other:

EMA, 2014